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Comment Wall (2 comments)

At 9:08pm on March 12, 2014, Dr Alain L Fymat said…

Thank you for your comment. In the development of pharmaceuticals, a common assumption is the use of the same dose for all patients. It makes it simple for, if there are multiple doses, there must be larger clinical trials and much more complex marketing. The starting dose typically represents the default dose that is rarely altered. The convenience of “one dose fits all” mentality could not be more advantageous to both drug manufacturers and … physicians. It is one of the essential elements of population medicine today, which I decry in my article above. However, how is it possible to conceive that we would all respond in the same way to the same dose of any given medication? With our extraordinary differences in health and physical condition, metabolism, genes, environmental exposures, age, gender, height, weight,…is there any single-dose drug that would be uniform in its effects for all of us? I do not and cannot believe it.

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